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The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences

The role of the cerebellum in schizophrenia has been highlighted by Andreasen's hypothesis of “cognitive dysmetria,” which suggests a general dyscoordination of sensorimotor and mental processes. Studies in schizophrenic patients have brought observations supporting a cerebellar impairment: hig...

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Autores principales: Picard, Hernàn, Amado, Isabelle, Mouchet-Mages, Sabine, Olié, Jean-Pierre, Krebs, Marie-Odile
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632376/
https://www.ncbi.nlm.nih.gov/pubmed/17562694
http://dx.doi.org/10.1093/schbul/sbm049
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author Picard, Hernàn
Amado, Isabelle
Mouchet-Mages, Sabine
Olié, Jean-Pierre
Krebs, Marie-Odile
author_facet Picard, Hernàn
Amado, Isabelle
Mouchet-Mages, Sabine
Olié, Jean-Pierre
Krebs, Marie-Odile
author_sort Picard, Hernàn
collection PubMed
description The role of the cerebellum in schizophrenia has been highlighted by Andreasen's hypothesis of “cognitive dysmetria,” which suggests a general dyscoordination of sensorimotor and mental processes. Studies in schizophrenic patients have brought observations supporting a cerebellar impairment: high prevalence of neurological soft signs, dyscoordination, abnormal posture and propioception, impaired eyeblink conditioning, impaired adaptation of the vestibular-ocular reflex or procedural learning tests, and lastly functional neuroimaging studies correlating poor cognitive performances with abnormal cerebellar activations. Despite those compelling evidences, there has been, to our knowledge, no recent review on the clinical, cognitive, and functional literature supporting the role of the cerebellum in schizophrenia. We conducted a Medline research focusing on cerebellar dysfunctions in schizophrenia. Emphasis was given to recent literature (after 1998). The picture arising from this review is heterogeneous. While in some domains, the role of the cerebellum seems clearly defined (ie, neurological soft signs, posture, or equilibrium), in other domains, the cerebellar contribution to schizophrenia seems limited or indirect (ie, cognition) if present at all (ie, affectivity). Functional models of the cerebellum are proposed as a background for interpreting these results.
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spelling pubmed-26323762009-02-12 The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences Picard, Hernàn Amado, Isabelle Mouchet-Mages, Sabine Olié, Jean-Pierre Krebs, Marie-Odile Schizophr Bull Regular Articles The role of the cerebellum in schizophrenia has been highlighted by Andreasen's hypothesis of “cognitive dysmetria,” which suggests a general dyscoordination of sensorimotor and mental processes. Studies in schizophrenic patients have brought observations supporting a cerebellar impairment: high prevalence of neurological soft signs, dyscoordination, abnormal posture and propioception, impaired eyeblink conditioning, impaired adaptation of the vestibular-ocular reflex or procedural learning tests, and lastly functional neuroimaging studies correlating poor cognitive performances with abnormal cerebellar activations. Despite those compelling evidences, there has been, to our knowledge, no recent review on the clinical, cognitive, and functional literature supporting the role of the cerebellum in schizophrenia. We conducted a Medline research focusing on cerebellar dysfunctions in schizophrenia. Emphasis was given to recent literature (after 1998). The picture arising from this review is heterogeneous. While in some domains, the role of the cerebellum seems clearly defined (ie, neurological soft signs, posture, or equilibrium), in other domains, the cerebellar contribution to schizophrenia seems limited or indirect (ie, cognition) if present at all (ie, affectivity). Functional models of the cerebellum are proposed as a background for interpreting these results. Oxford University Press 2008-01 2007-06-11 /pmc/articles/PMC2632376/ /pubmed/17562694 http://dx.doi.org/10.1093/schbul/sbm049 Text en © 2007 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Articles
Picard, Hernàn
Amado, Isabelle
Mouchet-Mages, Sabine
Olié, Jean-Pierre
Krebs, Marie-Odile
The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
title The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
title_full The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
title_fullStr The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
title_full_unstemmed The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
title_short The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences
title_sort role of the cerebellum in schizophrenia: an update of clinical, cognitive, and functional evidences
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632376/
https://www.ncbi.nlm.nih.gov/pubmed/17562694
http://dx.doi.org/10.1093/schbul/sbm049
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