Cargando…

Disruption of Vps4 and JNK Function in Drosophila Causes Tumour Growth

Several regulators of endocytic trafficking have recently been identified as tumour suppressors in Drosophila. These include components of the endosomal sorting complex required for transport (ESCRT) machinery. Disruption of subunits of ESCRT-I and –II leads to cell-autonomous endosomal accumulation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodahl, Lina M., Haglund, Kaisa, Sem-Jacobsen, Catherine, Wendler, Franz, Vincent, Jean-Paul, Lindmo, Karine, Rusten, Tor Erik, Stenmark, Harald
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632753/ https://www.ncbi.nlm.nih.gov/pubmed/19194501 http://dx.doi.org/10.1371/journal.pone.0004354

Ejemplares similares

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis
por: Pust, Sascha, et al.
Publicado: (2023)

Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila
por: Morelli, Elena, et al.
Publicado: (2015)

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
por: Nezis, Ioannis P., et al.
Publicado: (2008)

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
por: Nezis, Ioannis P., et al.
Publicado: (2010)

In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila
por: Wang, Hua-shan, et al.
Publicado: (2014)

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain
por: Vonk, Jan J., et al.
Publicado: (2017)

A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13
por: Dziurdzik, Samantha K, et al.
Publicado: (2020)

Microenvironment and tumors—a nurturing relationship
por: Katheder, Nadja Sandra, et al.
Publicado: (2017)

Vps54 Regulates Lifespan and Locomotor Behavior in Adult Drosophila melanogaster
por: Wilkinson, Emily C., et al.
Publicado: (2021)

JNK Signaling in Drosophila Aging and Longevity
por: Gan, Tian, et al.
Publicado: (2021)

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation
por: Knævelsrud, Helene, et al.
Publicado: (2013)

MiniCORVET is a Vps8-containing early endosomal tether in Drosophila
por: Lőrincz, Péter, et al.
Publicado: (2016)

Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility
por: Schmid, Martin R., et al.
Publicado: (2016)

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products
por: Seaman, Matthew N.J., et al.
Publicado: (1997)

Drosophila happyhour modulates JNK-dependent apoptosis
por: Lam, D, et al.
Publicado: (2010)

How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden
por: Stenmark, Harald
Publicado: (2010)

Ras(V12); scrib(−/−) Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
por: Dillard, Caroline, et al.
Publicado: (2021)

A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis
por: Sagona, Antonia P., et al.
Publicado: (2011)

MeHg-induced autophagy via JNK/Vps34 complex pathway promotes autophagosome accumulation and neuronal cell death
por: Lin, Tianji, et al.
Publicado: (2019)

Maintenance of Melanophore Morphology and Survival Is Cathepsin and vps11 Dependent in Zebrafish
por: Clancey, Lauren F., et al.
Publicado: (2013)

Vps28 Is Involved in the Intracellular Trafficking of Awd, the Drosophila Homolog of NME1/2
por: Mezzofanti, Elisa, et al.
Publicado: (2019)

JNK2 regulates vascular remodeling in pulmonary hypertension
por: Das, Mita, et al.
Publicado: (2018)

Design principles of the ESCRT-III Vps24-Vps2 module
por: Banjade, Sudeep, et al.
Publicado: (2021)

Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
por: Segala, Gregory, et al.
Publicado: (2019)

Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity
por: Takáts, Szabolcs, et al.
Publicado: (2015)

Wallenda regulates JNK-mediated cell death in Drosophila
por: Ma, X, et al.
Publicado: (2015)

GLYAT regulates JNK-mediated cell death in Drosophila
por: Ren, Pu, et al.
Publicado: (2017)

Lic regulates JNK‐mediated cell death in Drosophila
por: Sun, Yihao, et al.
Publicado: (2019)

Toll signaling promotes JNK-dependent apoptosis in Drosophila
por: Li, Zhuojie, et al.
Publicado: (2020)

Snail modulates JNK-mediated cell death in Drosophila
por: Wu, Chenxi, et al.
Publicado: (2019)

VPS13A and VPS13C Influence Lipid Droplet Abundance
por: Chen, Shuliang, et al.
Publicado: (2022)

The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins
por: Chimnaronk, Sarin, et al.
Publicado: (2015)

Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo
por: Holland, Petter, et al.
Publicado: (2021)

Dominant-negative VPS-4 disrupts ODR-10::GFP distribution but has limited effects on chemotaxis
por: Zocher, Ellen, et al.
Publicado: (2018)

PHLPP1 regulates CFTR activity and lumen expansion through AMPK
por: Lobert, Viola H., et al.
Publicado: (2022)

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
por: Juhász, Gábor, et al.
Publicado: (2008)

Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons
por: Insolera, Ryan, et al.
Publicado: (2021)

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
por: Platta, Harald W., et al.
Publicado: (2011)

Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila
por: Huang, Jiuhong, et al.
Publicado: (2015)

APLP2 Modulates JNK-Dependent Cell Migration in Drosophila
por: Wang, Xingjun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_path6u9hdnpeciaqgksiul7596