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A Ligand Channel through the G Protein Coupled Receptor Opsin

The G protein coupled receptor rhodopsin contains a pocket within its seven-transmembrane helix (TM) structure, which bears the inactivating 11-cis-retinal bound by a protonated Schiff-base to Lys296 in TM7. Light-induced 11-cis-/all-trans-isomerization leads to the Schiff-base deprotonated active M...

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Detalles Bibliográficos
Autores principales:	Hildebrand, Peter W., Scheerer, Patrick, Park, Jung Hee, Choe, Hui-Woog, Piechnick, Ronny, Ernst, Oliver P., Hofmann, Klaus Peter, Heck, Martin
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632885/ https://www.ncbi.nlm.nih.gov/pubmed/19194506 http://dx.doi.org/10.1371/journal.pone.0004382

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