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Molecular recognition of poly(A) by small ligands: an alternative method of analysis reveals nanomolar, cooperative and shape-selective binding
A few drug-like molecules have recently been found to bind poly(A) and induce a stable secondary structure (T(m) ≈ 60°C), even though this RNA homopolymer is single-stranded in the absence of a ligand. Here, we report results from experiments specifically designed to explore the association of small...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632892/ https://www.ncbi.nlm.nih.gov/pubmed/19073699 http://dx.doi.org/10.1093/nar/gkn977 |