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Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity

We previously reported that phosphorylation of topoisomerase (topo) IIα at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs. In this study we demonstrate that phosphorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein...

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Detalles Bibliográficos
Autores principales:	Grozav, Adrian G., Chikamori, Kenichi, Kozuki, Toshiyuki, Grabowski, Dale R., Bukowski, Ronald M., Willard, Belinda, Kinter, Michael, Andersen, Anni H., Ganapathi, Ram, Ganapathi, Mahrukh K.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632902/ https://www.ncbi.nlm.nih.gov/pubmed/19043076 http://dx.doi.org/10.1093/nar/gkn934

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