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An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins

Zinc-finger proteins (ZFPs) have long been recognized for their potential to manipulate genetic information because they can be engineered to bind novel DNA targets. Individual zinc-finger domains (ZFDs) bind specific DNA triplet sequences; their apparent modularity has led some groups to propose me...

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Detalles Bibliográficos
Autores principales:	Sander, Jeffry D., Zaback, Peter, Joung, J. Keith, Voytas, Daniel F., Dobbs, Drena
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632909/ https://www.ncbi.nlm.nih.gov/pubmed/19056825 http://dx.doi.org/10.1093/nar/gkn962

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