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Disease-Associated Mutant Ubiquitin Causes Proteasomal Impairment and Enhances the Toxicity of Protein Aggregates

Protein homeostasis is critical for cellular survival and its dysregulation has been implicated in Alzheimer's disease (AD) and other neurodegenerative disorders. Despite the growing appreciation of the pathogenic mechanisms involved in familial forms of AD, much less is known about the sporadi...

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Detalles Bibliográficos
Autores principales: Tank, Elizabeth M. H., True, Heather L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633047/
https://www.ncbi.nlm.nih.gov/pubmed/19214209
http://dx.doi.org/10.1371/journal.pgen.1000382

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