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A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
Resequencing is an emerging tool for identification of rare disease-associated mutations. Rare mutations are difficult to tag with SNP genotyping, as genotyping studies are designed to detect common variants. However, studies have shown that genetic heterogeneity is a probable scenario for common di...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633048/ https://www.ncbi.nlm.nih.gov/pubmed/19214210 http://dx.doi.org/10.1371/journal.pgen.1000384 |