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The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population

Reactive oxygen species have been known to be an important factor in the pathogenesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent anti-oxidant. We verified the effect of serum bilirubin level on the incidence of hypertension in normotensive subj...

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Autores principales: Chin, Ho Jun, Song, Young Rim, Kim, Hyo Sang, Park, Minseon, Yoon, Hyung Jin, Na, Ki Young, Kim, Yonsu, Chae, Dong-Wan, Kim, Suhnggwon
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633203/
https://www.ncbi.nlm.nih.gov/pubmed/19194562
http://dx.doi.org/10.3346/jkms.2009.24.S1.S50
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author Chin, Ho Jun
Song, Young Rim
Kim, Hyo Sang
Park, Minseon
Yoon, Hyung Jin
Na, Ki Young
Kim, Yonsu
Chae, Dong-Wan
Kim, Suhnggwon
author_facet Chin, Ho Jun
Song, Young Rim
Kim, Hyo Sang
Park, Minseon
Yoon, Hyung Jin
Na, Ki Young
Kim, Yonsu
Chae, Dong-Wan
Kim, Suhnggwon
author_sort Chin, Ho Jun
collection PubMed
description Reactive oxygen species have been known to be an important factor in the pathogenesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent anti-oxidant. We verified the effect of serum bilirubin level on the incidence of hypertension in normotensive subjects. We grouped 1,208 normotensive subjects by the criterion of the highest quintile value of serum bilirubin, 1.1 mg/dL. The incidence of hypertension was higher in group 1 with bilirubin less than 1.1 mg/dL than in group 2 with bilirubin 1.1 mg/dL or more (186/908 vs. 43/300, p=0.018). The relative risk for hypertension was 0.71 (95% confidence interval, 0.51-0.99), p=0.048 in group 2 compared to group 1 by Cox's proportional hazard model. Among the groups stratified by gender, smoking, and liver function status, the group 2 showed a lower risk of hypertension in females and in non-smokers. In conclusion, a mild increase within the physiological range of serum bilirubin concentration was negatively correlated with the incidence of hypertension. The effect of bilirubin on the development of hypertension was more evident in females and in non-smokers.
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spelling pubmed-26332032009-02-03 The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population Chin, Ho Jun Song, Young Rim Kim, Hyo Sang Park, Minseon Yoon, Hyung Jin Na, Ki Young Kim, Yonsu Chae, Dong-Wan Kim, Suhnggwon J Korean Med Sci Original Article Reactive oxygen species have been known to be an important factor in the pathogenesis of hypertension. Bilirubin, one of the metabolites of heme degraded by heme oxygenase, is a potent anti-oxidant. We verified the effect of serum bilirubin level on the incidence of hypertension in normotensive subjects. We grouped 1,208 normotensive subjects by the criterion of the highest quintile value of serum bilirubin, 1.1 mg/dL. The incidence of hypertension was higher in group 1 with bilirubin less than 1.1 mg/dL than in group 2 with bilirubin 1.1 mg/dL or more (186/908 vs. 43/300, p=0.018). The relative risk for hypertension was 0.71 (95% confidence interval, 0.51-0.99), p=0.048 in group 2 compared to group 1 by Cox's proportional hazard model. Among the groups stratified by gender, smoking, and liver function status, the group 2 showed a lower risk of hypertension in females and in non-smokers. In conclusion, a mild increase within the physiological range of serum bilirubin concentration was negatively correlated with the incidence of hypertension. The effect of bilirubin on the development of hypertension was more evident in females and in non-smokers. The Korean Academy of Medical Sciences 2009-01 2009-01-28 /pmc/articles/PMC2633203/ /pubmed/19194562 http://dx.doi.org/10.3346/jkms.2009.24.S1.S50 Text en Copyright © 2009 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chin, Ho Jun
Song, Young Rim
Kim, Hyo Sang
Park, Minseon
Yoon, Hyung Jin
Na, Ki Young
Kim, Yonsu
Chae, Dong-Wan
Kim, Suhnggwon
The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
title The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
title_full The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
title_fullStr The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
title_full_unstemmed The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
title_short The Bilirubin Level is Negatively Correlated with the Incidence of Hypertension in Normotensive Korean Population
title_sort bilirubin level is negatively correlated with the incidence of hypertension in normotensive korean population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633203/
https://www.ncbi.nlm.nih.gov/pubmed/19194562
http://dx.doi.org/10.3346/jkms.2009.24.S1.S50
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