Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development

Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25(high )regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25(...

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Detalles Bibliográficos
Autores principales: Milojevic, Diana, Nguyen, Khoa D, Wara, Diane, Mellins, Elizabeth D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633304/
https://www.ncbi.nlm.nih.gov/pubmed/19046457
http://dx.doi.org/10.1186/1546-0096-6-20
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author Milojevic, Diana
Nguyen, Khoa D
Wara, Diane
Mellins, Elizabeth D
author_facet Milojevic, Diana
Nguyen, Khoa D
Wara, Diane
Mellins, Elizabeth D
author_sort Milojevic, Diana
collection PubMed
description Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25(high )regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25(high )regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.
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spelling pubmed-26333042009-01-31 Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development Milojevic, Diana Nguyen, Khoa D Wara, Diane Mellins, Elizabeth D Pediatr Rheumatol Online J Review Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25(high )regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25(high )regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy. BioMed Central 2008-12-01 /pmc/articles/PMC2633304/ /pubmed/19046457 http://dx.doi.org/10.1186/1546-0096-6-20 Text en Copyright © 2008 Milojevic et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Milojevic, Diana
Nguyen, Khoa D
Wara, Diane
Mellins, Elizabeth D
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
title Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
title_full Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
title_fullStr Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
title_full_unstemmed Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
title_short Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
title_sort regulatory t cells and their role in rheumatic diseases: a potential target for novel therapeutic development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633304/
https://www.ncbi.nlm.nih.gov/pubmed/19046457
http://dx.doi.org/10.1186/1546-0096-6-20
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AT waradiane regulatorytcellsandtheirroleinrheumaticdiseasesapotentialtargetfornoveltherapeuticdevelopment
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