Inhibition of pituitary tumors in Rb mutant chimeras through E2f4-loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis

The retinoblastoma protein pRB suppresses tumorigenesis largely through regulation of the E2F transcription factors. E2F4, the most abundant E2F protein, is thought to act in cooperation with pRB to restrain cell proliferation. In this study, we analyze how loss of E2f4 affects the tumorigenicity of...

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Detalles Bibliográficos
Autores principales: Parisi, Tiziana, Bronson, Roderick T., Lees, Jacqueline A.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633419/
https://www.ncbi.nlm.nih.gov/pubmed/18997819
http://dx.doi.org/10.1038/onc.2008.406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633419/
https://www.ncbi.nlm.nih.gov/pubmed/18997819
http://dx.doi.org/10.1038/onc.2008.406

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