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The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis
In this review, the role of NF-κB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined. The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-κB in the livers of rats and mice. On the other hand, peroxisome prolifera...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633453/ https://www.ncbi.nlm.nih.gov/pubmed/19197377 http://dx.doi.org/10.1155/2008/286249 |
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author | Glauert, Howard P. Calfee-Mason, Karen Li, Yixin Nilakantan, Vani Twaroski, Michelle L. Tharappel, Job Spear, Brett T. |
author_facet | Glauert, Howard P. Calfee-Mason, Karen Li, Yixin Nilakantan, Vani Twaroski, Michelle L. Tharappel, Job Spear, Brett T. |
author_sort | Glauert, Howard P. |
collection | PubMed |
description | In this review, the role of NF-κB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined. The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-κB in the livers of rats and mice. On the other hand, peroxisome proliferator activated receptor-α (PPARα) activation in non-hepatic tissues can lead to the inhibition of NF-κB activation. Several lines of evidence support the hypothesis that the activation of NF-κB by peroxisome proliferators in the liver is mediated by oxidative stress. The role of NF-κB in peroxisome proliferator-induced hepatocarcinogenesis has been examined using NF-κB knockout models. Specifically, the induction of cell proliferation and the promotion of liver carcinogenesis are inhibited in mice lacking the p50 subunit of NF-κB. Overall, the activation of NF-κB appears to be important in the carcinogenic activity of peroxisome proliferators. |
format | Text |
id | pubmed-2633453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-26334532009-02-05 The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis Glauert, Howard P. Calfee-Mason, Karen Li, Yixin Nilakantan, Vani Twaroski, Michelle L. Tharappel, Job Spear, Brett T. PPAR Res Review Article In this review, the role of NF-κB in the induction of hepatocarcinogenesis by peroxisome proliferators is examined. The administration of peroxisome proliferators for more than a three-day period leads to the activation of NF-κB in the livers of rats and mice. On the other hand, peroxisome proliferator activated receptor-α (PPARα) activation in non-hepatic tissues can lead to the inhibition of NF-κB activation. Several lines of evidence support the hypothesis that the activation of NF-κB by peroxisome proliferators in the liver is mediated by oxidative stress. The role of NF-κB in peroxisome proliferator-induced hepatocarcinogenesis has been examined using NF-κB knockout models. Specifically, the induction of cell proliferation and the promotion of liver carcinogenesis are inhibited in mice lacking the p50 subunit of NF-κB. Overall, the activation of NF-κB appears to be important in the carcinogenic activity of peroxisome proliferators. Hindawi Publishing Corporation 2008 2009-01-29 /pmc/articles/PMC2633453/ /pubmed/19197377 http://dx.doi.org/10.1155/2008/286249 Text en Copyright © 2008 Howard P. Glauert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Glauert, Howard P. Calfee-Mason, Karen Li, Yixin Nilakantan, Vani Twaroski, Michelle L. Tharappel, Job Spear, Brett T. The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis |
title | The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis |
title_full | The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis |
title_fullStr | The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis |
title_full_unstemmed | The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis |
title_short | The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis |
title_sort | role of nf-κb in pparα-mediated hepatocarcinogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633453/ https://www.ncbi.nlm.nih.gov/pubmed/19197377 http://dx.doi.org/10.1155/2008/286249 |
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