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Deamidation alters interactions of β-crystallins in hetero-oligomers

PURPOSE: Cataracts are a major cause of blindness worldwide. A potential mechanism for loss of visual acuity may be due to light scattering from disruption of normal protein–protein interactions. During aging, the lens accumulates extensively deamidated crystallins. We have previously reported that...

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Detalles Bibliográficos
Autores principales: Takata, Takumi, Woodbury, Luke G., Lampi, Kirsten J.
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633459/
https://www.ncbi.nlm.nih.gov/pubmed/19190732