Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmiss...

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Autores principales: Béringue, Vincent, Herzog, Laëtitia, Reine, Fabienne, Le Dur, Annick, Casalone, Cristina, Vilotte, Jean-Luc, Laude, Hubert
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2008
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634647/
https://www.ncbi.nlm.nih.gov/pubmed/19046515
http://dx.doi.org/10.3201/eid1412.080941
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author Béringue, Vincent
Herzog, Laëtitia
Reine, Fabienne
Le Dur, Annick
Casalone, Cristina
Vilotte, Jean-Luc
Laude, Hubert
author_facet Béringue, Vincent
Herzog, Laëtitia
Reine, Fabienne
Le Dur, Annick
Casalone, Cristina
Vilotte, Jean-Luc
Laude, Hubert
author_sort Béringue, Vincent
collection PubMed
description To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
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spelling pubmed-26346472009-02-09 Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein Béringue, Vincent Herzog, Laëtitia Reine, Fabienne Le Dur, Annick Casalone, Cristina Vilotte, Jean-Luc Laude, Hubert Emerg Infect Dis Dispatch To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice. Centers for Disease Control and Prevention 2008-12 /pmc/articles/PMC2634647/ /pubmed/19046515 http://dx.doi.org/10.3201/eid1412.080941 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Béringue, Vincent
Herzog, Laëtitia
Reine, Fabienne
Le Dur, Annick
Casalone, Cristina
Vilotte, Jean-Luc
Laude, Hubert
Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
title Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
title_full Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
title_fullStr Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
title_full_unstemmed Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
title_short Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
title_sort transmission of atypical bovine prions to mice transgenic for human prion protein
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634647/
https://www.ncbi.nlm.nih.gov/pubmed/19046515
http://dx.doi.org/10.3201/eid1412.080941
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