The spliceosome as target for anticancer treatment

The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with...

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Detalles Bibliográficos
Autores principales: van Alphen, R J, Wiemer, E A C, Burger, H, Eskens, F A L M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634708/
https://www.ncbi.nlm.nih.gov/pubmed/19034274
http://dx.doi.org/10.1038/sj.bjc.6604801
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author van Alphen, R J
Wiemer, E A C
Burger, H
Eskens, F A L M
author_facet van Alphen, R J
Wiemer, E A C
Burger, H
Eskens, F A L M
author_sort van Alphen, R J
collection PubMed
description The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.
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spelling pubmed-26347082010-01-27 The spliceosome as target for anticancer treatment van Alphen, R J Wiemer, E A C Burger, H Eskens, F A L M Br J Cancer Review The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues. Nature Publishing Group 2009-01-27 2008-11-25 /pmc/articles/PMC2634708/ /pubmed/19034274 http://dx.doi.org/10.1038/sj.bjc.6604801 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
van Alphen, R J
Wiemer, E A C
Burger, H
Eskens, F A L M
The spliceosome as target for anticancer treatment
title The spliceosome as target for anticancer treatment
title_full The spliceosome as target for anticancer treatment
title_fullStr The spliceosome as target for anticancer treatment
title_full_unstemmed The spliceosome as target for anticancer treatment
title_short The spliceosome as target for anticancer treatment
title_sort spliceosome as target for anticancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634708/
https://www.ncbi.nlm.nih.gov/pubmed/19034274
http://dx.doi.org/10.1038/sj.bjc.6604801
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