Cargando…

Deficient mismatch repair system in patients with sporadic advanced colorectal cancer

A deficient mismatch repair system (dMMR) is present in 10–20% of patients with sporadic colorectal cancer (CRC) and is associated with a favourable prognosis in early stage disease. Data on patients with advanced disease are scarce. Our aim was to investigate the incidence and outcome of sporadic d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koopman, M, Kortman, G A M, Mekenkamp, L, Ligtenberg, M J L, Hoogerbrugge, N, Antonini, N F, Punt, C J A, van Krieken, J H J M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634718/ https://www.ncbi.nlm.nih.gov/pubmed/19165197 http://dx.doi.org/10.1038/sj.bjc.6604867

Ejemplares similares

Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases
por: Mekenkamp, L J M, et al.
Publicado: (2010)

Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer
por: Kim, Jong Beom, et al.
Publicado: (2021)

Prevalence and Prognosis of Lynch Syndrome and Sporadic Mismatch Repair Deficiency in Endometrial Cancer
por: Post, Cathalijne C B, et al.
Publicado: (2021)

Evaluation of yield and experiences of age‐related molecular investigation for heritable and nonheritable causes of mismatch repair deficient colorectal cancer to identify Lynch syndrome
por: Vos, Janet R., et al.
Publicado: (2020)

Minisatellite instability is found in colorectal tumours with mismatch repair deficiency
por: Coleman, M G, et al.
Publicado: (2001)

Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort
por: Zwart, Koen, et al.
Publicado: (2023)

Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer
por: Ramchander, Neal C., et al.
Publicado: (2020)

Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era
por: Wensink, G. Emerens, et al.
Publicado: (2020)

Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors
por: Kim, Hyunhee, et al.
Publicado: (2021)

Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer
por: Gong, Qing, et al.
Publicado: (2018)

Evaluating mismatch repair deficiency in colorectal cancer biopsy specimens
por: Grillo, F., et al.
Publicado: (2023)

Gastrointestinal ulceration as a possible side effect of bevacizumab which may herald perforation
por: Tol, J., et al.
Publicado: (2008)

Very low prevalence of germline MSH6 mutations in hereditary non-polyposis colorectal cancer suspected patients with colorectal cancer without microsatellite instability
por: Kets, C M, et al.
Publicado: (2006)

Mismatch repair genes status in sporadic Saudi colorectal cancer patients
por: Ata, Manar, et al.
Publicado: (2014)

Clinical significance of mismatch repair gene expression in sporadic colorectal cancer
por: SUN, ZHENQIANG, et al.
Publicado: (2014)

Establishment, Characterization and Chemosensitivity of Three Mismatch Repair Deficient Cell Lines from Sporadic and Inherited Colorectal Carcinomas
por: Maletzki, Claudia, et al.
Publicado: (2012)

Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma
por: Andachi, H, et al.
Publicado: (2002)

Challenges of Neoantigen Targeting in Lynch Syndrome and Constitutional Mismatch Repair Deficiency Syndrome
por: Abidi, Asima, et al.
Publicado: (2021)

Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients
por: Vymetalkova, Veronika Polakova, et al.
Publicado: (2014)

Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
por: Scarpa, Marco, et al.
Publicado: (2015)

Unexplained mismatch repair deficiency: Case closed
por: Eikenboom, Ellis L., et al.
Publicado: (2022)

Excluding Lynch syndrome in a female patient with metachronous DNA mismatch repair deficient colon- and ovarian cancer
por: Crobach, Stijn, et al.
Publicado: (2017)

Surveillance of women at high risk for hereditary ovarian cancer is inefficient
por: Oei, A L, et al.
Publicado: (2006)

UGT1A1(*)28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study
por: Kweekel, D M, et al.
Publicado: (2008)

Improving calculation, interpretation and communication of familial colorectal cancer risk: Protocol for a randomized controlled trial
por: Dekker, Nicky, et al.
Publicado: (2010)

Pembrolizumab in Asian patients with microsatellite‐instability‐high/mismatch‐repair‐deficient colorectal cancer
por: Yoshino, Takayuki, et al.
Publicado: (2022)

Psychological distress in newly diagnosed colorectal cancer patients following microsatellite instability testing for Lynch syndrome on the pathologist’s initiative
por: Landsbergen, K. M., et al.
Publicado: (2012)

Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair‐deficient colorectal cancer
por: Ryan, É. J., et al.
Publicado: (2018)

KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients
por: Knijn, N, et al.
Publicado: (2011)

Efficacy of immunotherapy in mismatch repair-deficient advanced colorectal cancer in routine clinical practice. An AGEO study
por: Alouani, E., et al.
Publicado: (2023)

Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours
por: Ghimenti, C, et al.
Publicado: (1999)

Advances in genetic technologies result in improved diagnosis of mismatch repair deficiency in colorectal and endometrial cancers
por: Evans, D Gareth, et al.
Publicado: (2022)

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer
por: Ricker, Charité N., et al.
Publicado: (2017)

Gastric Medullary Carcinoma with Sporadic Mismatch Repair Deficiency and a TP53 R273C Mutation: An Unusual Case with Wild-Type BRAF
por: Lowenthal, Brett M., et al.
Publicado: (2017)

DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers
por: Caja, Fabian, et al.
Publicado: (2020)

Most Patients with Colorectal Tumors at Young Age Do Not Visit a Cancer Genetics Clinic
por: Overbeek, Lucia I. H., et al.
Publicado: (2008)

Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer
por: Song, Yurong, et al.
Publicado: (2023)

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
por: Westcott, Peter M. K., et al.
Publicado: (2023)

Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer
por: Zhang, Cong-Min, et al.
Publicado: (2016)

Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment
por: Zhang, Yingyi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r9n9en41s5teu36hb5l6e4dlcl