LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition

LKB1/STK11 is a multitasking tumour suppressor kinase. Germline inactivating mutations of the gene are responsible for the Peutz-Jeghers hereditary cancer syndrome. It is also somatically inactivated in approximately 30% of non-small-cell lung cancer (NSCLC). Here, we report that LKB1/KRAS mutant NS...

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Detalles Bibliográficos
Autores principales: Mahoney, C L, Choudhury, B, Davies, H, Edkins, S, Greenman, C, Haaften, G van, Mironenko, T, Santarius, T, Stevens, C, Stratton, M R, Futreal, P A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634725/
https://www.ncbi.nlm.nih.gov/pubmed/19165201
http://dx.doi.org/10.1038/sj.bjc.6604886

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