Direct effects of doxorubicin on skeletal muscle contribute to fatigue

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Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation fol...

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Detalles Bibliográficos
Autores principales: van Norren, K, van Helvoort, A, Argilés, J M, van Tuijl, S, Arts, Karin, Gorselink, M, Laviano, A, Kegler, D, Haagsman, H P, van der Beek, E M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634729/
https://www.ncbi.nlm.nih.gov/pubmed/19165199
http://dx.doi.org/10.1038/sj.bjc.6604858
Descripción
Sumario:Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation followed in time by contraction impediment, which could be explained by DOX-induced changes in Ca(2+) responses of myotubes in vitro. The Ca(2+) responses in skeletal muscle, however, could not be explained by oxidative stress.

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