Direct effects of doxorubicin on skeletal muscle contribute to fatigue

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Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation fol...

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Autores principales: van Norren, K, van Helvoort, A, Argilés, J M, van Tuijl, S, Arts, Karin, Gorselink, M, Laviano, A, Kegler, D, Haagsman, H P, van der Beek, E M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634729/
https://www.ncbi.nlm.nih.gov/pubmed/19165199
http://dx.doi.org/10.1038/sj.bjc.6604858
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author van Norren, K
van Helvoort, A
Argilés, J M
van Tuijl, S
Arts, Karin
Gorselink, M
Laviano, A
Kegler, D
Haagsman, H P
van der Beek, E M
author_facet van Norren, K
van Helvoort, A
Argilés, J M
van Tuijl, S
Arts, Karin
Gorselink, M
Laviano, A
Kegler, D
Haagsman, H P
van der Beek, E M
author_sort van Norren, K
collection PubMed
description Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation followed in time by contraction impediment, which could be explained by DOX-induced changes in Ca(2+) responses of myotubes in vitro. The Ca(2+) responses in skeletal muscle, however, could not be explained by oxidative stress.
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spelling pubmed-26347292010-01-27 Direct effects of doxorubicin on skeletal muscle contribute to fatigue van Norren, K van Helvoort, A Argilés, J M van Tuijl, S Arts, Karin Gorselink, M Laviano, A Kegler, D Haagsman, H P van der Beek, E M Br J Cancer Short Communication Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation followed in time by contraction impediment, which could be explained by DOX-induced changes in Ca(2+) responses of myotubes in vitro. The Ca(2+) responses in skeletal muscle, however, could not be explained by oxidative stress. Nature Publishing Group 2009-01-27 2009-01-13 /pmc/articles/PMC2634729/ /pubmed/19165199 http://dx.doi.org/10.1038/sj.bjc.6604858 Text en Copyright © 2009 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
van Norren, K
van Helvoort, A
Argilés, J M
van Tuijl, S
Arts, Karin
Gorselink, M
Laviano, A
Kegler, D
Haagsman, H P
van der Beek, E M
Direct effects of doxorubicin on skeletal muscle contribute to fatigue
title Direct effects of doxorubicin on skeletal muscle contribute to fatigue
title_full Direct effects of doxorubicin on skeletal muscle contribute to fatigue
title_fullStr Direct effects of doxorubicin on skeletal muscle contribute to fatigue
title_full_unstemmed Direct effects of doxorubicin on skeletal muscle contribute to fatigue
title_short Direct effects of doxorubicin on skeletal muscle contribute to fatigue
title_sort direct effects of doxorubicin on skeletal muscle contribute to fatigue
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634729/
https://www.ncbi.nlm.nih.gov/pubmed/19165199
http://dx.doi.org/10.1038/sj.bjc.6604858
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