Mutation Patterns in the Human Genome: More Variable Than Expected

Why are some genomic positions more mutable than others? The identification of cryptic mutation hotspots in the human genome indicates that the determinants of mutation rates are more complex than anticipated.

Detalles Bibliográficos
Autor principal: Duret, Laurent
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634789/
https://www.ncbi.nlm.nih.gov/pubmed/19192948
http://dx.doi.org/10.1371/journal.pbio.1000028
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author Duret, Laurent
author_facet Duret, Laurent
author_sort Duret, Laurent
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description Why are some genomic positions more mutable than others? The identification of cryptic mutation hotspots in the human genome indicates that the determinants of mutation rates are more complex than anticipated.
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spelling pubmed-26347892009-03-07 Mutation Patterns in the Human Genome: More Variable Than Expected Duret, Laurent PLoS Biol Primer Why are some genomic positions more mutable than others? The identification of cryptic mutation hotspots in the human genome indicates that the determinants of mutation rates are more complex than anticipated. Public Library of Science 2009-02 2009-02-03 /pmc/articles/PMC2634789/ /pubmed/19192948 http://dx.doi.org/10.1371/journal.pbio.1000028 Text en : © 2009 Laurent Duret. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Primer
Duret, Laurent
Mutation Patterns in the Human Genome: More Variable Than Expected
title Mutation Patterns in the Human Genome: More Variable Than Expected
title_full Mutation Patterns in the Human Genome: More Variable Than Expected
title_fullStr Mutation Patterns in the Human Genome: More Variable Than Expected
title_full_unstemmed Mutation Patterns in the Human Genome: More Variable Than Expected
title_short Mutation Patterns in the Human Genome: More Variable Than Expected
title_sort mutation patterns in the human genome: more variable than expected
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634789/
https://www.ncbi.nlm.nih.gov/pubmed/19192948
http://dx.doi.org/10.1371/journal.pbio.1000028
work_keys_str_mv AT duretlaurent mutationpatternsinthehumangenomemorevariablethanexpected

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