Poisoning Pyridoxal 5-Phosphate-Dependent Enzymes: A New Strategy to Target the Malaria Parasite Plasmodium falciparum

The human malaria parasite Plasmodium falciparum is able to synthesize de novo pyridoxal 5-phosphate (PLP), a crucial cofactor, during erythrocytic schizogony. However, the parasite possesses additionally a pyridoxine/pyridoxal kinase (PdxK) to activate B6 vitamers salvaged from the host. We describ...

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Detalles Bibliográficos
Autores principales: Müller, Ingrid B., Wu, Fang, Bergmann, Bärbel, Knöckel, Julia, Walter, Rolf D., Gehring, Heinz, Wrenger, Carsten
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634962/
https://www.ncbi.nlm.nih.gov/pubmed/19197387
http://dx.doi.org/10.1371/journal.pone.0004406

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