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Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis

Late infantile neuronal ceroid lipofuscinosis is a fatal childhood neurological disorder caused by a deficiency in the lysosomal protease tripeptidyl-peptidase 1 (TPP1). TPP1 represents the only known mammalian member of the S53 family of serine proteases, a group characterized by a subtilisin-like...

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Detalles Bibliográficos
Autores principales:	Guhaniyogi, Jayita, Sohar, Istvan, Das, Kalyan, Stock, Ann M., Lobel, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635056/ https://www.ncbi.nlm.nih.gov/pubmed/19038967 http://dx.doi.org/10.1074/jbc.M806943200

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