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NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity

BACKGROUND: Neutrophil cytosolic factor 1, p47(phox )(NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseud...

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Autores principales: Greve, Bernhard, Hoffmann, Peter, Vonthein, Reinhard, Kun, Jürgen, Lell, Bertrand, Mycko, Marcin P, Selmaj, Krysztof W, Berger, Klaus, Weissert, Robert, Kremsner, Peter G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635379/
https://www.ncbi.nlm.nih.gov/pubmed/19077231
http://dx.doi.org/10.1186/1475-2875-7-251
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author Greve, Bernhard
Hoffmann, Peter
Vonthein, Reinhard
Kun, Jürgen
Lell, Bertrand
Mycko, Marcin P
Selmaj, Krysztof W
Berger, Klaus
Weissert, Robert
Kremsner, Peter G
author_facet Greve, Bernhard
Hoffmann, Peter
Vonthein, Reinhard
Kun, Jürgen
Lell, Bertrand
Mycko, Marcin P
Selmaj, Krysztof W
Berger, Klaus
Weissert, Robert
Kremsner, Peter G
author_sort Greve, Bernhard
collection PubMed
description BACKGROUND: Neutrophil cytosolic factor 1, p47(phox )(NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. METHODS: NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). RESULTS: Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. CONCLUSION: The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.
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spelling pubmed-26353792009-02-04 NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity Greve, Bernhard Hoffmann, Peter Vonthein, Reinhard Kun, Jürgen Lell, Bertrand Mycko, Marcin P Selmaj, Krysztof W Berger, Klaus Weissert, Robert Kremsner, Peter G Malar J Research BACKGROUND: Neutrophil cytosolic factor 1, p47(phox )(NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. METHODS: NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). RESULTS: Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. CONCLUSION: The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS. BioMed Central 2008-12-11 /pmc/articles/PMC2635379/ /pubmed/19077231 http://dx.doi.org/10.1186/1475-2875-7-251 Text en Copyright © 2008 Greve et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Greve, Bernhard
Hoffmann, Peter
Vonthein, Reinhard
Kun, Jürgen
Lell, Bertrand
Mycko, Marcin P
Selmaj, Krysztof W
Berger, Klaus
Weissert, Robert
Kremsner, Peter G
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
title NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
title_full NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
title_fullStr NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
title_full_unstemmed NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
title_short NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
title_sort ncf1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635379/
https://www.ncbi.nlm.nih.gov/pubmed/19077231
http://dx.doi.org/10.1186/1475-2875-7-251
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