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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

The Spindle Assembly Checkpoint (SAC) is required to block sister chromatid separation until all chromosomes are properly attached to the mitotic apparatus. The SAC prevents cells entering anaphase by inhibiting the ubiquitination of cyclin B1 and securin by the Anaphase Promoting Complex/Cyclosome...

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Detalles Bibliográficos
Autores principales:	Nilsson, Jakob, Yekezare, Mona, Minshull, Jeremy, Pines, Jonathon
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635557/ https://www.ncbi.nlm.nih.gov/pubmed/18997788 http://dx.doi.org/10.1038/ncb1799

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