Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in co...

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Autores principales: Szliszka, Ewelina, Czuba, Zenon P., Jernas, Katarzyna, Król, Wojciech
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2008
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635601/
https://www.ncbi.nlm.nih.gov/pubmed/19325719
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author Szliszka, Ewelina
Czuba, Zenon P.
Jernas, Katarzyna
Król, Wojciech
author_facet Szliszka, Ewelina
Czuba, Zenon P.
Jernas, Katarzyna
Król, Wojciech
author_sort Szliszka, Ewelina
collection PubMed
description TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.
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spelling pubmed-26356012009-03-25 Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Szliszka, Ewelina Czuba, Zenon P. Jernas, Katarzyna Król, Wojciech Int J Mol Sci Full Research Paper TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect. Molecular Diversity Preservation International (MDPI) 2008-01-21 /pmc/articles/PMC2635601/ /pubmed/19325719 Text en © 2008 by MDPI
spellingShingle Full Research Paper
Szliszka, Ewelina
Czuba, Zenon P.
Jernas, Katarzyna
Król, Wojciech
Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_full Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_fullStr Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_full_unstemmed Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_short Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_sort dietary flavonoids sensitize hela cells to tumor necrosis factor-related apoptosis-inducing ligand (trail)
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635601/
https://www.ncbi.nlm.nih.gov/pubmed/19325719
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AT jernaskatarzyna dietaryflavonoidssensitizehelacellstotumornecrosisfactorrelatedapoptosisinducingligandtrail
AT krolwojciech dietaryflavonoidssensitizehelacellstotumornecrosisfactorrelatedapoptosisinducingligandtrail

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