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Discovery of Proteomic Code with mRNA Assisted Protein Folding

The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is addit...

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Detalles Bibliográficos
Autor principal: Biro, Jan C
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635648/
https://www.ncbi.nlm.nih.gov/pubmed/19330085
http://dx.doi.org/10.3390/ijms9122424
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author Biro, Jan C
author_facet Biro, Jan C
author_sort Biro, Jan C
collection PubMed
description The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding.
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spelling pubmed-26356482009-03-25 Discovery of Proteomic Code with mRNA Assisted Protein Folding Biro, Jan C Int J Mol Sci Review The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding. Molecular Diversity Preservation International (MDPI) 2008-12-03 /pmc/articles/PMC2635648/ /pubmed/19330085 http://dx.doi.org/10.3390/ijms9122424 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Biro, Jan C
Discovery of Proteomic Code with mRNA Assisted Protein Folding
title Discovery of Proteomic Code with mRNA Assisted Protein Folding
title_full Discovery of Proteomic Code with mRNA Assisted Protein Folding
title_fullStr Discovery of Proteomic Code with mRNA Assisted Protein Folding
title_full_unstemmed Discovery of Proteomic Code with mRNA Assisted Protein Folding
title_short Discovery of Proteomic Code with mRNA Assisted Protein Folding
title_sort discovery of proteomic code with mrna assisted protein folding
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635648/
https://www.ncbi.nlm.nih.gov/pubmed/19330085
http://dx.doi.org/10.3390/ijms9122424
work_keys_str_mv AT birojanc discoveryofproteomiccodewithmrnaassistedproteinfolding