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Discovery of Proteomic Code with mRNA Assisted Protein Folding
The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is addit...
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635648/ https://www.ncbi.nlm.nih.gov/pubmed/19330085 http://dx.doi.org/10.3390/ijms9122424 |
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author | Biro, Jan C |
author_facet | Biro, Jan C |
author_sort | Biro, Jan C |
collection | PubMed |
description | The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding. |
format | Text |
id | pubmed-2635648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-26356482009-03-25 Discovery of Proteomic Code with mRNA Assisted Protein Folding Biro, Jan C Int J Mol Sci Review The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding. Molecular Diversity Preservation International (MDPI) 2008-12-03 /pmc/articles/PMC2635648/ /pubmed/19330085 http://dx.doi.org/10.3390/ijms9122424 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Biro, Jan C Discovery of Proteomic Code with mRNA Assisted Protein Folding |
title | Discovery of Proteomic Code with mRNA Assisted Protein Folding |
title_full | Discovery of Proteomic Code with mRNA Assisted Protein Folding |
title_fullStr | Discovery of Proteomic Code with mRNA Assisted Protein Folding |
title_full_unstemmed | Discovery of Proteomic Code with mRNA Assisted Protein Folding |
title_short | Discovery of Proteomic Code with mRNA Assisted Protein Folding |
title_sort | discovery of proteomic code with mrna assisted protein folding |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635648/ https://www.ncbi.nlm.nih.gov/pubmed/19330085 http://dx.doi.org/10.3390/ijms9122424 |
work_keys_str_mv | AT birojanc discoveryofproteomiccodewithmrnaassistedproteinfolding |