CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Ke-Tai, Paul, Angela, Schichor, Christian, Ziemer, Gerhard, Wendel, Hans P.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635693/
https://www.ncbi.nlm.nih.gov/pubmed/19325777
_version_ 1782164214012444672
author Guo, Ke-Tai
Paul, Angela
Schichor, Christian
Ziemer, Gerhard
Wendel, Hans P.
author_facet Guo, Ke-Tai
Paul, Angela
Schichor, Christian
Ziemer, Gerhard
Wendel, Hans P.
author_sort Guo, Ke-Tai
collection PubMed
description Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.
format Text
id pubmed-2635693
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-26356932009-03-25 CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics Guo, Ke-Tai Paul, Angela Schichor, Christian Ziemer, Gerhard Wendel, Hans P. Int J Mol Sci Review Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers. Molecular Diversity Preservation International (MDPI) 2008-04-24 /pmc/articles/PMC2635693/ /pubmed/19325777 Text en © 2008 by MDPI
spellingShingle Review
Guo, Ke-Tai
Paul, Angela
Schichor, Christian
Ziemer, Gerhard
Wendel, Hans P.
CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
title CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
title_full CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
title_fullStr CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
title_full_unstemmed CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
title_short CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
title_sort cell-selex: novel perspectives of aptamer-based therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635693/
https://www.ncbi.nlm.nih.gov/pubmed/19325777
work_keys_str_mv AT guoketai cellselexnovelperspectivesofaptamerbasedtherapeutics
AT paulangela cellselexnovelperspectivesofaptamerbasedtherapeutics
AT schichorchristian cellselexnovelperspectivesofaptamerbasedtherapeutics
AT ziemergerhard cellselexnovelperspectivesofaptamerbasedtherapeutics
AT wendelhansp cellselexnovelperspectivesofaptamerbasedtherapeutics

Ejemplares similares