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Synthesis and Biological Evaluation of a Novel Pentagastrin-Toxin Conjugate Designed for a Targeted Prodrug Mono-therapy of Cancer

A novel carbamate prodrug 2 containing a pentagastrin moiety was synthesized. 2 was designed as a detoxified analogue of the highly cytotoxic natural antibiotic duocarmycin SA (1) for the use in a targeted prodrug monotherapy of cancers expressing cholecystokinin (CCK-B)/gastrin receptors. The synth...

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Detalles Bibliográficos
Autores principales:	Tietze, Lutz F., Panknin, Olaf, Krewer, Birgit, Major, Felix, Schuberth, Ingrid
Formato:	Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635707/ https://www.ncbi.nlm.nih.gov/pubmed/19325786 http://dx.doi.org/10.3390/ijms9050821

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