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Genetic Ablation of Bcl-x Attenuates Invasiveness without Affecting Apoptosis or Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Cancer

Tumor cell death is modulated by an intrinsic cell death pathway controlled by the pro- and anti-apoptotic members of the Bcl-2 family. Up-regulation of anti-apoptotic Bcl-2 family members has been shown to suppress cell death in pre-clinical models of human cancer and is implicated in human tumor p...

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Detalles Bibliográficos
Autores principales:	Hager, Jeffrey H., Ulanet, Danielle B., Hennighausen, Lothar, Hanahan, Douglas
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635964/ https://www.ncbi.nlm.nih.gov/pubmed/19209227 http://dx.doi.org/10.1371/journal.pone.0004455

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