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A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course

Optic pathway glioma associated with neurofibromatosis 1 has a classically indolent course. However, involvement of the optic radiations is relatively rare and is associated with a more aggressive course. A three-year-old girl presented with strabismus and loss of vision in the left eye with relativ...

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Autores principales: Ganesh, Suma, Gupta, Archana, Sharma, Manish, Bhuttan, Samdeep
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636080/
https://www.ncbi.nlm.nih.gov/pubmed/18292634
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author Ganesh, Suma
Gupta, Archana
Sharma, Manish
Bhuttan, Samdeep
author_facet Ganesh, Suma
Gupta, Archana
Sharma, Manish
Bhuttan, Samdeep
author_sort Ganesh, Suma
collection PubMed
description Optic pathway glioma associated with neurofibromatosis 1 has a classically indolent course. However, involvement of the optic radiations is relatively rare and is associated with a more aggressive course. A three-year-old girl presented with strabismus and loss of vision in the left eye with relative afferent pupillary defect and optic disc pallor. She had multiple café au lait spots. Visually evoked potential was suggestive of an optic nerve conduction defect and magnetic resonance imaging of the brain was suggestive of an optic pathway glioma involving the optic nerves, the optic chiasma and the optic tracts. The optic radiations and the dentate nuclei had hamartomas. Optic nerve biopsy confirmed pilocytic astrocytoma. Radical radiotherapy under general anesthesia was subsequently given. This case report aims to highlight the involvement of the optic radiations and the unusually aggressive clinical course in this case.
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spelling pubmed-26360802009-02-10 A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course Ganesh, Suma Gupta, Archana Sharma, Manish Bhuttan, Samdeep Indian J Ophthalmol Brief Communication Optic pathway glioma associated with neurofibromatosis 1 has a classically indolent course. However, involvement of the optic radiations is relatively rare and is associated with a more aggressive course. A three-year-old girl presented with strabismus and loss of vision in the left eye with relative afferent pupillary defect and optic disc pallor. She had multiple café au lait spots. Visually evoked potential was suggestive of an optic nerve conduction defect and magnetic resonance imaging of the brain was suggestive of an optic pathway glioma involving the optic nerves, the optic chiasma and the optic tracts. The optic radiations and the dentate nuclei had hamartomas. Optic nerve biopsy confirmed pilocytic astrocytoma. Radical radiotherapy under general anesthesia was subsequently given. This case report aims to highlight the involvement of the optic radiations and the unusually aggressive clinical course in this case. Medknow Publications 2008 /pmc/articles/PMC2636080/ /pubmed/18292634 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Ganesh, Suma
Gupta, Archana
Sharma, Manish
Bhuttan, Samdeep
A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
title A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
title_full A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
title_fullStr A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
title_full_unstemmed A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
title_short A case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
title_sort case of neurofibromatosis 1 presenting with optic pathway glioma with an early onset and an aggressive course
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636080/
https://www.ncbi.nlm.nih.gov/pubmed/18292634
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