Voriconazole for the treatment of refractory Aspergillus fumigatus keratitis

We report a case of Aspergillus fumigatus keratitis in a 53-year-old, well-controlled diabetic female who did not respond to standard antifungal treatment. She was started on topical natamycin eye drops, but the infiltrate continued to progress. Topical amphotericin B and systemic ketoconazole was a...

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Detalles Bibliográficos
Autores principales: Mehta, Hijab, Mehta, Hitendra B, Garg, Prashant, Kodial, Harish
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636104/
https://www.ncbi.nlm.nih.gov/pubmed/18417831
Descripción
Sumario:We report a case of Aspergillus fumigatus keratitis in a 53-year-old, well-controlled diabetic female who did not respond to standard antifungal treatment. She was started on topical natamycin eye drops, but the infiltrate continued to progress. Topical amphotericin B and systemic ketoconazole was added, however, there was no response and the infiltrate increased further. She was then switched to topical and systemic voriconazole. Steady resolution of the infiltrate was noted within 2 weeks of therapy.

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