Neurotrophic keratitis in a patient with dihydroxypyrimidine dehydrogenase deficiency

We describe a case of neurotrophic keratitis in association with dihydroxypyrimidine dehydrogenase (DHPD) deficiency. Ocular manifestations in patients with DHPD are rare and neurotrophic keratitis has never been reported before. A six-year- old boy who was a known case of DHPD deficiency and born o...

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Detalles Bibliográficos
Autores principales: Kapoor, Bharat, Luhishi, Ezzedin A, Chung, Andrew K K, Pauw, Jakobus C
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636154/
https://www.ncbi.nlm.nih.gov/pubmed/18580000
Descripción
Sumario:We describe a case of neurotrophic keratitis in association with dihydroxypyrimidine dehydrogenase (DHPD) deficiency. Ocular manifestations in patients with DHPD are rare and neurotrophic keratitis has never been reported before. A six-year- old boy who was a known case of DHPD deficiency and born of a consanguineous marriage presented to our clinic with non- healing corneal ulcers in both eyes. Reduced corneal sensations were detected and the patient was started on lubricating eye drops. The patient continues to be on lubricant eye drops and there has been no recurrence of the disease.

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