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A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma
Gliomas, the most common malignant tumors of the nervous system, frequently harbor mutations that activate the epidermal growth factor receptor (EGFR) and phosphatidylinositol-3 kinase (PI3K) signaling pathways. To investigate the genetic basis of this disease, we developed a glioma model in Drosoph...
Autores principales: | Read, Renee D., Cavenee, Webster K., Furnari, Frank B., Thomas, John B. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636203/ https://www.ncbi.nlm.nih.gov/pubmed/19214224 http://dx.doi.org/10.1371/journal.pgen.1000374 |
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