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The Integrin Antagonist Cilengitide Activates αVβ3, Disrupts VE-Cadherin Localization at Cell Junctions and Enhances Permeability in Endothelial Cells

Cilengitide is a high-affinity cyclic pentapeptdic αV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through αVβ3/αVβ5 integrins. Angiogenic endothelial cells express multiple integrins, in particular those of the β1 family, and lit...

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Detalles Bibliográficos
Autores principales:	Alghisi, Gian Carlo, Ponsonnet, Lionel, Rüegg, Curzio
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636874/ https://www.ncbi.nlm.nih.gov/pubmed/19212436 http://dx.doi.org/10.1371/journal.pone.0004449

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