Inoculation of Scrapie with the Self-Assembling RADA-Peptide Disrupts Prion Accumulation and Extends Hamster Survival

Intracerebral inoculation of 263K Scrapie brain homogenate (PrPsc) with a self-assembling RADA-peptide (RADA) significantly delayed disease onset and increased hamster survival. Time of survival was dependent on the dose of RADA and pre-incubation with PrPsc prior to inoculation. RADA treatment resu...

Descripción completa

Detalles Bibliográficos
Autores principales: Hnasko, Robert, Bruederle, Cathrin E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636877/
https://www.ncbi.nlm.nih.gov/pubmed/19212437
http://dx.doi.org/10.1371/journal.pone.0004440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636877/
https://www.ncbi.nlm.nih.gov/pubmed/19212437
http://dx.doi.org/10.1371/journal.pone.0004440

Ejemplares similares