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Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology

INTRODUCTION: Variance component QTL methodology was used to analyse three candidate regions on chicken chromosomes 1, 4 and 5 for dominant and parent-of-origin QTL effects. Data were available for bodyweight and conformation score measured at 40 days from a two-generation commercial broiler dam lin...

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Autores principales: Rowe, Suzanne J, Pong-Wong, Ricardo, Haley, Christopher S, Knott, Sara A, De Koning, Dirk-Jan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637028/
https://www.ncbi.nlm.nih.gov/pubmed/19284678
http://dx.doi.org/10.1186/1297-9686-41-6
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author Rowe, Suzanne J
Pong-Wong, Ricardo
Haley, Christopher S
Knott, Sara A
De Koning, Dirk-Jan
author_facet Rowe, Suzanne J
Pong-Wong, Ricardo
Haley, Christopher S
Knott, Sara A
De Koning, Dirk-Jan
author_sort Rowe, Suzanne J
collection PubMed
description INTRODUCTION: Variance component QTL methodology was used to analyse three candidate regions on chicken chromosomes 1, 4 and 5 for dominant and parent-of-origin QTL effects. Data were available for bodyweight and conformation score measured at 40 days from a two-generation commercial broiler dam line. One hundred dams were nested in 46 sires with phenotypes and genotypes on 2708 offspring. Linear models were constructed to simultaneously estimate fixed, polygenic and QTL effects. Different genetic models were compared using likelihood ratio test statistics derived from the comparison of full with reduced or null models. Empirical thresholds were derived by permutation analysis. RESULTS: Dominant QTL were found for bodyweight on chicken chromosome 4 and for bodyweight and conformation score on chicken chromosome 5. Suggestive evidence for a maternally expressed QTL for bodyweight and conformation score was found on chromosome 1 in a region corresponding to orthologous imprinted regions in the human and mouse. CONCLUSION: Initial results suggest that variance component analysis can be applied within commercial populations for the direct detection of segregating dominant and parent of origin effects.
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spelling pubmed-26370282009-02-12 Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology Rowe, Suzanne J Pong-Wong, Ricardo Haley, Christopher S Knott, Sara A De Koning, Dirk-Jan Genet Sel Evol Research INTRODUCTION: Variance component QTL methodology was used to analyse three candidate regions on chicken chromosomes 1, 4 and 5 for dominant and parent-of-origin QTL effects. Data were available for bodyweight and conformation score measured at 40 days from a two-generation commercial broiler dam line. One hundred dams were nested in 46 sires with phenotypes and genotypes on 2708 offspring. Linear models were constructed to simultaneously estimate fixed, polygenic and QTL effects. Different genetic models were compared using likelihood ratio test statistics derived from the comparison of full with reduced or null models. Empirical thresholds were derived by permutation analysis. RESULTS: Dominant QTL were found for bodyweight on chicken chromosome 4 and for bodyweight and conformation score on chicken chromosome 5. Suggestive evidence for a maternally expressed QTL for bodyweight and conformation score was found on chromosome 1 in a region corresponding to orthologous imprinted regions in the human and mouse. CONCLUSION: Initial results suggest that variance component analysis can be applied within commercial populations for the direct detection of segregating dominant and parent of origin effects. BioMed Central 2009-01-05 /pmc/articles/PMC2637028/ /pubmed/19284678 http://dx.doi.org/10.1186/1297-9686-41-6 Text en Copyright © 2009 Rowe et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rowe, Suzanne J
Pong-Wong, Ricardo
Haley, Christopher S
Knott, Sara A
De Koning, Dirk-Jan
Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology
title Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology
title_full Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology
title_fullStr Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology
title_full_unstemmed Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology
title_short Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology
title_sort detecting parent of origin and dominant qtl in a two-generation commercial poultry pedigree using variance component methodology
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637028/
https://www.ncbi.nlm.nih.gov/pubmed/19284678
http://dx.doi.org/10.1186/1297-9686-41-6
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