A Comprehensive Comparison of the Continual Reassessment Method to the Standard 3 + 3 Dose Escalation Scheme in Phase I Dose-Finding Studies

BACKGROUND: An extensive literature has covered the statistical properties of the Continual Reassessment Method (CRM) and the modifications of this method. While there are some applications of CRM designs in recent Phase I trials, the standard method (SM) of escalating doses after three patients wit...

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Detalles Bibliográficos
Autores principales: Iasonos, Alexia, Wilton, Andrew S, Riedel, Elyn R, Seshan, Venkatraman E, Spriggs, David R
Formato: Texto
Lenguaje:English
Publicado: SAGE Publications 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637378/
https://www.ncbi.nlm.nih.gov/pubmed/18827039
http://dx.doi.org/10.1177/1740774508096474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637378/
https://www.ncbi.nlm.nih.gov/pubmed/18827039
http://dx.doi.org/10.1177/1740774508096474

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