Heterozygous Mutation of Opa1 in Drosophila Shortens Lifespan Mediated through Increased Reactive Oxygen Species Production

Optic atrophy 1 (OPA1) is a dynamin-like GTPase located in the inner mitochondrial membrane and mutations in OPA1 are associated with autosomal dominant optic atrophy (DOA). OPA1 plays important roles in mitochondrial fusion, cristae remodeling and apoptosis. Our previous study showed that dOpa1 mut...

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Detalles Bibliográficos
Autores principales: Tang, Sha, Le, Phung Khanh, Tse, Stephanie, Wallace, Douglas C., Huang, Taosheng
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637430/
https://www.ncbi.nlm.nih.gov/pubmed/19221591
http://dx.doi.org/10.1371/journal.pone.0004492

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