Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis

Converging evidence leaves little doubt that a change in the conformation of prion protein (PrP(C)) from a mainly α-helical to a β-sheet rich PrP-scrapie (PrP(Sc)) form is the main event responsible for prion disease associated neurotoxicity. However, neither the mechanism of toxicity by PrP(Sc), no...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Ajay, Mohan, Maradumane L., Isaac, Alfred Orina, Luo, Xiu, Petrak, Jiri, Vyoral, Daniel, Singh, Neena
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637434/
https://www.ncbi.nlm.nih.gov/pubmed/19212444
http://dx.doi.org/10.1371/journal.pone.0004468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637434/
https://www.ncbi.nlm.nih.gov/pubmed/19212444
http://dx.doi.org/10.1371/journal.pone.0004468

Ejemplares similares