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Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis
Converging evidence leaves little doubt that a change in the conformation of prion protein (PrP(C)) from a mainly α-helical to a β-sheet rich PrP-scrapie (PrP(Sc)) form is the main event responsible for prion disease associated neurotoxicity. However, neither the mechanism of toxicity by PrP(Sc), no...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637434/ https://www.ncbi.nlm.nih.gov/pubmed/19212444 http://dx.doi.org/10.1371/journal.pone.0004468 |