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Disrupted ‘reflection’ impulsivity in cannabis users but not current or former ecstasy users
Evidence for serotonin involvement in impulsivity has generated interest in the measurement of impulsivity in regular ecstasy users, who are thought to display serotonergic dysfunction. However, current findings are inconsistent. Here, we used a recently developed Information Sampling Test to measur...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Sage
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637477/ https://www.ncbi.nlm.nih.gov/pubmed/18515464 http://dx.doi.org/10.1177/0269881108089587 |
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author | Clark, L Roiser, JP Robbins, TW Sahakian, BJ |
author_facet | Clark, L Roiser, JP Robbins, TW Sahakian, BJ |
author_sort | Clark, L |
collection | PubMed |
description | Evidence for serotonin involvement in impulsivity has generated interest in the measurement of impulsivity in regular ecstasy users, who are thought to display serotonergic dysfunction. However, current findings are inconsistent. Here, we used a recently developed Information Sampling Test to measure ‘reflection’ impulsivity in 46 current ecstasy users, 14 subjects who used ecstasy in the past, 15 current cannabis users and 19 drug-naïve controls. Despite elevated scores on the Impulsivity subscale of the Eysenck Impulsiveness-Venturesomeness-Empathy questionnaire, the current and previous ecstasy users did not differ significantly from the drug-naive controls on the Information Sampling Test. In contrast, the cannabis users sampled significantly less information on the task, and tolerated a lower level of certainty in their decision-making, in comparison to the drug-naive controls. The effect in cannabis users extends our earlier observations in amphetamine- and opiate-dependent individuals (Clark, et al., 2006, Biological Psychiatry 60: 515–522), and suggests that reduced reflection may be a common cognitive style across regular users of a variety of substances. However, the lack of effects in the two ecstasy groups suggests that the relationship between serotonin function, ecstasy use and impulsivity is more complex. |
format | Text |
id | pubmed-2637477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Sage |
record_format | MEDLINE/PubMed |
spelling | pubmed-26374772009-02-10 Disrupted ‘reflection’ impulsivity in cannabis users but not current or former ecstasy users Clark, L Roiser, JP Robbins, TW Sahakian, BJ J Psychopharmacol Original Papers Evidence for serotonin involvement in impulsivity has generated interest in the measurement of impulsivity in regular ecstasy users, who are thought to display serotonergic dysfunction. However, current findings are inconsistent. Here, we used a recently developed Information Sampling Test to measure ‘reflection’ impulsivity in 46 current ecstasy users, 14 subjects who used ecstasy in the past, 15 current cannabis users and 19 drug-naïve controls. Despite elevated scores on the Impulsivity subscale of the Eysenck Impulsiveness-Venturesomeness-Empathy questionnaire, the current and previous ecstasy users did not differ significantly from the drug-naive controls on the Information Sampling Test. In contrast, the cannabis users sampled significantly less information on the task, and tolerated a lower level of certainty in their decision-making, in comparison to the drug-naive controls. The effect in cannabis users extends our earlier observations in amphetamine- and opiate-dependent individuals (Clark, et al., 2006, Biological Psychiatry 60: 515–522), and suggests that reduced reflection may be a common cognitive style across regular users of a variety of substances. However, the lack of effects in the two ecstasy groups suggests that the relationship between serotonin function, ecstasy use and impulsivity is more complex. Sage 2009-01-01 /pmc/articles/PMC2637477/ /pubmed/18515464 http://dx.doi.org/10.1177/0269881108089587 Text en © 2009 British Association for Psychopharmacology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Papers Clark, L Roiser, JP Robbins, TW Sahakian, BJ Disrupted ‘reflection’ impulsivity in cannabis users but not current or former ecstasy users |
title | Disrupted ‘reflection’ impulsivity in cannabis
users but not current or former ecstasy users |
title_full | Disrupted ‘reflection’ impulsivity in cannabis
users but not current or former ecstasy users |
title_fullStr | Disrupted ‘reflection’ impulsivity in cannabis
users but not current or former ecstasy users |
title_full_unstemmed | Disrupted ‘reflection’ impulsivity in cannabis
users but not current or former ecstasy users |
title_short | Disrupted ‘reflection’ impulsivity in cannabis
users but not current or former ecstasy users |
title_sort | disrupted ‘reflection’ impulsivity in cannabis
users but not current or former ecstasy users |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637477/ https://www.ncbi.nlm.nih.gov/pubmed/18515464 http://dx.doi.org/10.1177/0269881108089587 |
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