Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

Reduced expression of Paneth cell antimicrobial α-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differentiation, directly regulates the expression of HD...

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Detalles Bibliográficos
Autores principales: Koslowski, Maureen J., Kübler, Irmgard, Chamaillard, Mathias, Schaeffeler, Elke, Reinisch, Walter, Wang, Guoxing, Beisner, Julia, Teml, Alexander, Peyrin-Biroulet, Laurent, Winter, Stefan, Herrlinger, Klaus R., Rutgeerts, Paul, Vermeire, Séverine, Cooney, Rachel, Fellermann, Klaus, Jewell, Derek, Bevins, Charles L., Schwab, Matthias, Stange, Eduard F., Wehkamp, Jan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637978/
https://www.ncbi.nlm.nih.gov/pubmed/19221600
http://dx.doi.org/10.1371/journal.pone.0004496

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