High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

BACKGROUND: Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons, artemisinin is often in short supply, and ferm...

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Detalles Bibliográficos
Autores principales: Tsuruta, Hiroko, Paddon, Christopher J., Eng, Diana, Lenihan, Jacob R., Horning, Tizita, Anthony, Larry C., Regentin, Rika, Keasling, Jay D., Renninger, Neil S., Newman, Jack D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637983/
https://www.ncbi.nlm.nih.gov/pubmed/19221601
http://dx.doi.org/10.1371/journal.pone.0004489

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