Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

Dysfunction and loss of insulin-producing pancreatic β cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38δ display improved glucose tolerance due to enhanced insulin secretion from pancreatic β cells. Deletion of p38δ resul...

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Detalles Bibliográficos
Autores principales: Sumara, Grzegorz, Formentini, Ivan, Collins, Stephan, Sumara, Izabela, Windak, Renata, Bodenmiller, Bernd, Ramracheya, Reshma, Caille, Dorothée, Jiang, Huiping, Platt, Kenneth A., Meda, Paolo, Aebersold, Rudolf, Rorsman, Patrik, Ricci, Romeo
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638021/
https://www.ncbi.nlm.nih.gov/pubmed/19135240
http://dx.doi.org/10.1016/j.cell.2008.11.018

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