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Intracellular Proton-Transfer Mutants in a CLC Cl(−)/H(+) Exchanger
CLC-ec1, a bacterial homologue of the CLC family’s transporter subclass, catalyzes transmembrane exchange of Cl(−) and H(+). Mutational analysis based on the known structure reveals several key residues required for coupling H(+) to the stoichiometric countermovement of Cl(−). E148 (Glu(ex)) transfe...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638202/ https://www.ncbi.nlm.nih.gov/pubmed/19139174 http://dx.doi.org/10.1085/jgp.200810112 |