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Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study

African American Men are 65% more likely to develop prostate cancer and are twice as likely to die of prostate cancer, than are Caucasian American Males. The explanation for this glaring health disparity is still unknown; although a number of different plausible factors have been offered including g...

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Autores principales: Reams, R Renee, Agrawal, Deepak, Davis, Melissa B, Yoder, Sean, Odedina, Folakemi T, Kumar, Nagi, Higginbotham, Joseph M, Akinremi, Titilola, Suther, Sandra, Soliman, Karam FA
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638462/
https://www.ncbi.nlm.nih.gov/pubmed/19208208
http://dx.doi.org/10.1186/1750-9378-4-S1-S3
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author Reams, R Renee
Agrawal, Deepak
Davis, Melissa B
Yoder, Sean
Odedina, Folakemi T
Kumar, Nagi
Higginbotham, Joseph M
Akinremi, Titilola
Suther, Sandra
Soliman, Karam FA
author_facet Reams, R Renee
Agrawal, Deepak
Davis, Melissa B
Yoder, Sean
Odedina, Folakemi T
Kumar, Nagi
Higginbotham, Joseph M
Akinremi, Titilola
Suther, Sandra
Soliman, Karam FA
author_sort Reams, R Renee
collection PubMed
description African American Men are 65% more likely to develop prostate cancer and are twice as likely to die of prostate cancer, than are Caucasian American Males. The explanation for this glaring health disparity is still unknown; although a number of different plausible factors have been offered including genetic susceptibility and gene-environment interactions. We favor the hypothesis that altered gene expression plays a major role in the disparity observed in prostate cancer incidence and mortality between African American and Caucasian American Males. To discover genes or gene expression pattern(s) unique to African American or to Caucasian American Males that explain the observed prostate cancer health disparity in African American males, we conducted a micro array pilot project study that used prostate tumors with a Gleason score of 6. We compared gene expression profiling in tumors from African-American Males to prostate tumors in Caucasian American Males. A comparison of case-matched ratios revealed at least 67 statistically significant genes that met filtering criteria of at least +/- 4.0 fold change and p < 0.0001. Gene ontology terms prevalent in African American prostate tumor/normal ratios relative to Caucasian American prostate tumor/normal ratios included interleukins, progesterone signaling, Chromatin-mediated maintenance and myeloid dendritic cell proliferation. Functional in vitro assays are underway to determine roles that selected genes in these onotologies play in contributing to prostate cancer development and health disparity.
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spelling pubmed-26384622009-02-11 Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study Reams, R Renee Agrawal, Deepak Davis, Melissa B Yoder, Sean Odedina, Folakemi T Kumar, Nagi Higginbotham, Joseph M Akinremi, Titilola Suther, Sandra Soliman, Karam FA Infect Agent Cancer Proceedings African American Men are 65% more likely to develop prostate cancer and are twice as likely to die of prostate cancer, than are Caucasian American Males. The explanation for this glaring health disparity is still unknown; although a number of different plausible factors have been offered including genetic susceptibility and gene-environment interactions. We favor the hypothesis that altered gene expression plays a major role in the disparity observed in prostate cancer incidence and mortality between African American and Caucasian American Males. To discover genes or gene expression pattern(s) unique to African American or to Caucasian American Males that explain the observed prostate cancer health disparity in African American males, we conducted a micro array pilot project study that used prostate tumors with a Gleason score of 6. We compared gene expression profiling in tumors from African-American Males to prostate tumors in Caucasian American Males. A comparison of case-matched ratios revealed at least 67 statistically significant genes that met filtering criteria of at least +/- 4.0 fold change and p < 0.0001. Gene ontology terms prevalent in African American prostate tumor/normal ratios relative to Caucasian American prostate tumor/normal ratios included interleukins, progesterone signaling, Chromatin-mediated maintenance and myeloid dendritic cell proliferation. Functional in vitro assays are underway to determine roles that selected genes in these onotologies play in contributing to prostate cancer development and health disparity. BioMed Central 2009-02-10 /pmc/articles/PMC2638462/ /pubmed/19208208 http://dx.doi.org/10.1186/1750-9378-4-S1-S3 Text en Copyright © 2009 Reams et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Reams, R Renee
Agrawal, Deepak
Davis, Melissa B
Yoder, Sean
Odedina, Folakemi T
Kumar, Nagi
Higginbotham, Joseph M
Akinremi, Titilola
Suther, Sandra
Soliman, Karam FA
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
title Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
title_full Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
title_fullStr Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
title_full_unstemmed Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
title_short Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
title_sort microarray comparison of prostate tumor gene expression in african-american and caucasian american males: a pilot project study
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638462/
https://www.ncbi.nlm.nih.gov/pubmed/19208208
http://dx.doi.org/10.1186/1750-9378-4-S1-S3
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