Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

In order to identify new genes with differential expression in early intestinal tumours, we performed mRNA (messenger ribonucleic acid) expression profiling of 16 human and 63 mouse adenomas. All individuals had germline APC mutations to ensure that tumorigenesis was driven by ‘second hits’ at APC....

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Detalles Bibliográficos
Autores principales: Segditsas, Stefania, Sieber, Oliver, Deheragoda, Maesha, East, Phil, Rowan, Andrew, Jeffery, Rosemary, Nye, Emma, Clark, Susan, Spencer-Dene, Bradley, Stamp, Gordon, Poulsom, Richard, Suraweera, Nirosha, Silver, Andrew, Ilyas, Mohammad, Tomlinson, Ian
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638572/
https://www.ncbi.nlm.nih.gov/pubmed/18782851
http://dx.doi.org/10.1093/hmg/ddn286

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