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Synaptosomal Toxicity and Nucleophilic Targets of 4-Hydroxy-2-Nonenal

4-Hydroxy-2-nonenal (HNE) is an aldehyde by-product of lipid peroxidation that is presumed to play a primary role in certain neuropathogenic states (e.g., Alzheimer disease, spinal cord trauma). Although the molecular mechanism of neurotoxicity is unknown, proteomic analyses (e.g., tandem mass spect...

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Detalles Bibliográficos
Autores principales:	LoPachin, Richard M., Geohagen, Brian C., Gavin, Terrence
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Neurotoxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638640/ https://www.ncbi.nlm.nih.gov/pubmed/18996889 http://dx.doi.org/10.1093/toxsci/kfn226

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