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The NMDA Agonist D-Cycloserine Facilitates Fear Memory Consolidation in Humans

Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycl...

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Detalles Bibliográficos
Autores principales: Kalisch, Raffael, Holt, Beatrice, Petrovic, Predrag, De Martino, Benedetto, Klöppel, Stefan, Büchel, Christian, Dolan, Raymond J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638747/
https://www.ncbi.nlm.nih.gov/pubmed/18477687
http://dx.doi.org/10.1093/cercor/bhn076
Descripción
Sumario:Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.