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Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey

In human most cortical γ-aminobutyric acidergic (GABAergic) neurons are produced in the proliferative zones of the dorsal telencephalon in contrast to rodents. We report that in cynomolgus monkey fetuses cortical GABAergic neurons are generated in the proliferative zones of the dorsal telencephalon,...

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Autores principales: Petanjek, Zdravko, Berger, Brigitte, Esclapez, Monique
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638783/
https://www.ncbi.nlm.nih.gov/pubmed/18477686
http://dx.doi.org/10.1093/cercor/bhn078
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author Petanjek, Zdravko
Berger, Brigitte
Esclapez, Monique
author_facet Petanjek, Zdravko
Berger, Brigitte
Esclapez, Monique
author_sort Petanjek, Zdravko
collection PubMed
description In human most cortical γ-aminobutyric acidergic (GABAergic) neurons are produced in the proliferative zones of the dorsal telencephalon in contrast to rodents. We report that in cynomolgus monkey fetuses cortical GABAergic neurons are generated in the proliferative zones of the dorsal telencephalon, in addition to the proliferative region of the ventral telencephalon, the ganglionic eminence (GE), however, with a temporal delay. GABAergic neuron progenitors labeled for Mash1 and GAD65 were present mainly in the GE at embryonic days (E) 47–55, and in the entire dorsal telencephalon at E64–75. These progenitors within the dorsal telencephalon are generated locally rather than in the GE. The ventral and dorsal lineages of cortical GABAergic neurons display different laminar distribution. Early generated GABAergic neurons from the GE mostly populate the marginal zone and subplate, whereas cortical plate GABAergic neurons originate from both ventral and dorsal telencephalon. A differential regulation of the two GABA synthesizing enzymes (GAD65 and GAD67) parallels GABAergic neuron differentiation. GAD65 is preferentially expressed in GABAergic progenitors and migrating neurons, GAD67 in morphologically differentiated neurons. Therefore, the dorsal telencephalic origin of cortical GABAergic neurons is not human-specific but appears as a former event in the ascent of evolution that could provide GABAergic neurons to an expending neocortex.
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spelling pubmed-26387832009-02-25 Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey Petanjek, Zdravko Berger, Brigitte Esclapez, Monique Cereb Cortex Articles In human most cortical γ-aminobutyric acidergic (GABAergic) neurons are produced in the proliferative zones of the dorsal telencephalon in contrast to rodents. We report that in cynomolgus monkey fetuses cortical GABAergic neurons are generated in the proliferative zones of the dorsal telencephalon, in addition to the proliferative region of the ventral telencephalon, the ganglionic eminence (GE), however, with a temporal delay. GABAergic neuron progenitors labeled for Mash1 and GAD65 were present mainly in the GE at embryonic days (E) 47–55, and in the entire dorsal telencephalon at E64–75. These progenitors within the dorsal telencephalon are generated locally rather than in the GE. The ventral and dorsal lineages of cortical GABAergic neurons display different laminar distribution. Early generated GABAergic neurons from the GE mostly populate the marginal zone and subplate, whereas cortical plate GABAergic neurons originate from both ventral and dorsal telencephalon. A differential regulation of the two GABA synthesizing enzymes (GAD65 and GAD67) parallels GABAergic neuron differentiation. GAD65 is preferentially expressed in GABAergic progenitors and migrating neurons, GAD67 in morphologically differentiated neurons. Therefore, the dorsal telencephalic origin of cortical GABAergic neurons is not human-specific but appears as a former event in the ascent of evolution that could provide GABAergic neurons to an expending neocortex. Oxford University Press 2009-02 2008-05-13 /pmc/articles/PMC2638783/ /pubmed/18477686 http://dx.doi.org/10.1093/cercor/bhn078 Text en © 2008 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Petanjek, Zdravko
Berger, Brigitte
Esclapez, Monique
Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
title Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
title_full Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
title_fullStr Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
title_full_unstemmed Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
title_short Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
title_sort origins of cortical gabaergic neurons in the cynomolgus monkey
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638783/
https://www.ncbi.nlm.nih.gov/pubmed/18477686
http://dx.doi.org/10.1093/cercor/bhn078
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